Effect of lead toxicity on coenzyme Q levels in rat tissues.

نویسندگان

  • Gamil M Abdallah
  • El-Sayed M El-Sayed
  • Osama M Abo-Salem
چکیده

Lead is a persistent and common environmental contaminant, which chiefly plays a significant role in modern industry. Coenzyme Q acts as electron and proton carrier in mitochondria and functions as an antioxidant in its reduced form (ubiquinol). To investigate the hazardous effects of lead on the coenzyme Q level, rats were injected i.p. with lead acetate (5 mg/kg b.wt. daily for 6 weeks). Our results showed that the levels of both oxidized (ubiquinone) and reduced (ubiquinol) forms of coenzyme Q(9) and Q(10) in serum, brain, liver and kidney of lead-treated rats are quite different depending on the organ tissue type.

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عنوان ژورنال:
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

دوره 48 6  شماره 

صفحات  -

تاریخ انتشار 2010